Ataxic v. painful form of paraneoplastic neuropathy

Oki Y, Koike H, Iijima M et al. Neurology 2007; 69:564-572.

Group one-- dep sensory disturbance, shows sensory ataxia, markedly abnormal sural nerve,

Group 2-- superficial sensory disturbance- shows severe hyperalgesia, involvement small myelinated fibers and unmyelinated fibers.

Both groups showed an axonal sensory neuropathy with greater diminution of SNAPs in first (sensory ataxia) group. Both groups had about 50% presence of antiHu antibodies. Both groups had some cases with benefit from treating the cancer; immunotherapy was of transient benefit.