Nerve conductions in POEMS synrdome

Presentation is symmetric peripheral neuropathy resembling CIDP, with areflexia and mixed demyelinating.axonal features. The systemic features include organomegaly, endocrinopathy, monoclonal serum protein ( M protein), and dermatologic abnormalities In a study of 138 patients with POEMS seen over 47 years, Mauermann et al found slowed motor and sensory velocity, prolonged distal latiencues and F waves. However, unlike CIDP there was rarely temporal dispersion or conduction block.